Exercising lab-grown human muscle autonomously blocks the damaging effects of interferon-gamma

Biomedical engineers at Duke University have demonstrated that human muscle has an innate ability to ward off chronic inflammation’s damaging effects when exercised. The discovery was made possible through the use of lab-grown, engineered human muscle, demonstrating the potential power of the first-of-its-kind platform in such research endeavors.

The results appear online on January 22 in the journal Science Advances.

“Lots of processes are taking place throughout the human body during exercise, and it is difficult to tease apart which systems and cells are doing what inside an active person,” said Nenad Bursac, professor of biomedical engineering at Duke. “Our…


One side of the colon ages faster than the other, scientists reveal

New research reveals the colons of African-Americans and people of European descent age differently, helping explain racial disparities in colorectal cancer — cancer that killed beloved “Black Panther” star Chadwick Boseman only 43.

Scientists led by UVA Health’s Li Li, MD, Ph.D.; Graham Casey, Ph.D.; and Matt Devall, Ph.D., of the Center for Public Health Genomics, found one side of the colon ages biologically faster than the other in both African-Americans and people of European descent. …


With a significant part of the global population forced to work from home, lower back pain may increase. Lithuanian scientists have devised a spinal stabilization exercise program for managing lower back pain for people who perform a sedentary job. After testing the program with 70 volunteers, the researchers have found that the exercises are not only efficient in diminishing the non-specific lower back pain, but their effect lasts 3 times longer than that of a usual muscle strengthening exercise program.

According to the World Health Organisation, lower back pain is among the top 10 diseases and injuries that decrease the…


In a study to examine a Mediterranean diet about prostate cancer progression in men on active surveillance, researchers from The University of Texas MD Anderson Cancer Center found that men with localized prostate cancer who reported a baseline dietary pattern that more closely follows the key principles of a Mediterranean-style diet fared better over the course of their disease.

“Men with prostate cancer are motivated to find a way to impact the advancement of their disease and improve their quality of life,” said Justin Gregg, M.D., assistant professor of Urology and lead author of the study, published today in Cancer


Men and women aged over 50 can reap similar relative benefits from resistance training, a new study led by UNSW Sydney shows.

While men are likely to gain absolute muscle size, the gains relative to body size are on par with women’s.

The findings, recently published in Sports Medicine, consolidated 30 different resistance training studies involving over 1400 participants. This paper specifically compared the results of men and women aged 50 and over.

“Historically, people tended to believe that men adapted to a greater degree from resistance training compared to women,” says Dr. …


Findings from the Nurses’ Health Study, one of the longest-running studies of women’s health, show that five diet and lifestyle factors, including regular exercise, can significantly impact gastroesophageal reflux (GERD) heartburn symptoms. GERD is a common condition affecting about a third of the U.S. population; the main symptom is heartburn, and it is often managed with medications. However, this new study suggests that following diet and lifestyle guidelines may substantially reduce symptoms and make medication unnecessary for some patients. It was published as a letter in JAMA Internal Medicine.

The five factors include normal weight, never smoking, moderate-to-vigorous physical activity…


COVID-19 is associated with life-threatening blood clots in the arteries of the legs, according to a study published in Radiology. Researchers said COVID-19 patients with symptoms of inadequate blood supply to the lower extremities tend to have larger clots and a significantly higher rate of amputation and death than uninfected people with the same condition.

COVID-19’s association with blood clots in the pulmonary arteries is well-established. Less is known about the virus’s connection to lower extremity arterial thrombosis, a condition characterized by blood clots in the arteries that impede oxygenated blood flow to the lower extremities.

During the peak of…


More than one in three respondents reported clinically significant levels of depression, exceeding rates seen before 2020

Though childbirth is often anticipated with optimism and enthusiasm, approximately 10 to 20 percent of pregnant individuals also experience mental health challenges during the weeks immediately before and after birth. Depression, anxiety, and trauma-related disorders can all be exacerbated by increased stress related to pregnancy and postpartum experiences. But it’s unknown how the stressors of a significant health pandemic can impact these complications. …


Each week, millions of runners worldwide lace up their running shoes, spurred on by the psychological, health, and social benefits that running delivers.

The birth of Parkrun in 2004 — now an international activity with more than 20 countries involved — is credited with a sharp rise in the popularity of running in the past decade, but with benefits come downsides.

A new research paper by the University of South Australia Adjunct Professor Jan de Jonge and his team reveals the price that runners (and society) pay when the sport becomes an obsession.

Based in the Netherlands at Eindhoven University…


The study identifies a novel compound in the fight against antibiotic resistance

As scientists around the globe wage war against a novel, a deadly virus, one University of Colorado Boulder lab is working on new weapons to battle a different microbial threat: a rising tide of antibiotic-resistant bacteria which, if left unchecked, could kill an estimated 10 million people annually by 2050.

“The COVID-19 situation is definitely putting us at risk for increasing resistance to antibiotics, so it’s more important now than ever that we come up with alternative treatments,” said Corrie Detweiler, a professor of molecular, cellular, and developmental biology who has spent her career seeking those alternatives.

In a paper…

Carson Whitaker

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